Antitumor potential of natural products from marine ascidians of the Gibraltar Strait: A survey

Antitumor potential of natural products from marine ascidians of the Gibraltar Strait: A survey

The chemical study of a selection of marine ascidians from the Gibraltar Strait has led to the characterization of a collection of natural products of diverse biosynthetic origin. The structures were elucidated by spectroscopic methods and, in certain instances, the absolute stereochemistry was dete...

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Autores principales: Zubía, E, Ortega, MJ, Salvá, J
Formato: Online
Idioma:eng
Publicado em: Iniversidad Autónoma de Baja California 2003
Acesso em linha:https://www.cienciasmarinas.com.mx/index.php/cmarinas/article/view/141
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spelling oai:cienciasmarinas.com.mx:article-1412019-04-26T22:58:04Z Antitumor potential of natural products from marine ascidians of the Gibraltar Strait: A survey Potencialidad antitumoral de productos naturales marinos de ascidias del Estrecho de Gibraltar: Una panorámica Zubía, E Ortega, MJ Salvá, J natural products ascidians structure elucidation cytotoxicity productos naturales ascidias elucidación estructural citotoxicidad The chemical study of a selection of marine ascidians from the Gibraltar Strait has led to the characterization of a collection of natural products of diverse biosynthetic origin. The structures were elucidated by spectroscopic methods and, in certain instances, the absolute stereochemistry was determined using chiral auxiliaries following the Mosher method. In particular, the new compounds isolated from the ascidians Phallusia fumigata (Grübe, 1864), Botryllus leachi (Savigny, 1816), Stolonica socialis (Hartmayer, 1903), and Pseudodistoma obscurum (Pères, 1959) are presented and key aspects of the structural elucidation are discussed. In order to anticipate a possible antitumor application, the cytotoxicity of the new compounds was evaluated against cell lines P-388 (suspension culture of a lymphoid neoplasm from a DBA/2 mouse), A-549 (monolayer culture of a human lung carcinoma), HT-29 (monolayer culture of a human colon carcinoma), and MEL-28 (monolayer culture of a human melanoma). El estudio químico de una serie de ascidias seleccionadas procedentes del Estrecho de Gibraltar ha llevado a la caracterización de una colección de productos naturales de muy diverso origen biosintético. Las estructuras se establecieron mediante métodos espectroscópicos y, en algunos casos, la estereoquímica absoluta se determinó usando auxiliares quirales siguiendo el método de Mosher. En concreto, se presentan los nuevos compuestos aislados a partir de las ascidias Phallusia fumigata (Grübe, 1864), Botryllus leachi (Savigny, 1816), Stolonica socialis (Hartmayer, 1903) y Pseudodistoma obscurum (Pères, 1959) y se discuten aspectos clave acerca de la elucidación estructural. Para poder anticipar una posible aplicación antitumoral, se ha realizado una evaluación de citotoxicidad de los nuevos compuestos frente a las líneas celulares P-388 (cultivo en suspensión de un neoplasma linfoide de ratón DBA/2), A-549 (cultivo en monocapa de un carcinoma de pulmón humano), HT-29 (cultivo en monocapa de un carcinoma de colon humano) y MEL-28 (cultivo en monocapa de un melanoma humano). Iniversidad Autónoma de Baja California 2003-03-06 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article Artículo Arbitrado application/pdf https://www.cienciasmarinas.com.mx/index.php/cmarinas/article/view/141 10.7773/cm.v29i2.141 Ciencias Marinas; Vol. 29 No. 2 (2003); 251-260 Ciencias Marinas; Vol. 29 Núm. 2 (2003); 251-260 2395-9053 0185-3880 eng https://www.cienciasmarinas.com.mx/index.php/cmarinas/article/view/141/117
institution Ciencias Marinas
collection OJS
language eng
format Online
author Zubía, E
Ortega, MJ
Salvá, J
spellingShingle Zubía, E
Ortega, MJ
Salvá, J
Antitumor potential of natural products from marine ascidians of the Gibraltar Strait: A survey
author_facet Zubía, E
Ortega, MJ
Salvá, J
author_sort Zubía, E
title Antitumor potential of natural products from marine ascidians of the Gibraltar Strait: A survey
title_short Antitumor potential of natural products from marine ascidians of the Gibraltar Strait: A survey
title_full Antitumor potential of natural products from marine ascidians of the Gibraltar Strait: A survey
title_fullStr Antitumor potential of natural products from marine ascidians of the Gibraltar Strait: A survey
title_full_unstemmed Antitumor potential of natural products from marine ascidians of the Gibraltar Strait: A survey
title_sort antitumor potential of natural products from marine ascidians of the gibraltar strait: a survey
description The chemical study of a selection of marine ascidians from the Gibraltar Strait has led to the characterization of a collection of natural products of diverse biosynthetic origin. The structures were elucidated by spectroscopic methods and, in certain instances, the absolute stereochemistry was determined using chiral auxiliaries following the Mosher method. In particular, the new compounds isolated from the ascidians Phallusia fumigata (Grübe, 1864), Botryllus leachi (Savigny, 1816), Stolonica socialis (Hartmayer, 1903), and Pseudodistoma obscurum (Pères, 1959) are presented and key aspects of the structural elucidation are discussed. In order to anticipate a possible antitumor application, the cytotoxicity of the new compounds was evaluated against cell lines P-388 (suspension culture of a lymphoid neoplasm from a DBA/2 mouse), A-549 (monolayer culture of a human lung carcinoma), HT-29 (monolayer culture of a human colon carcinoma), and MEL-28 (monolayer culture of a human melanoma).
publisher Iniversidad Autónoma de Baja California
publishDate 2003
url https://www.cienciasmarinas.com.mx/index.php/cmarinas/article/view/141
_version_ 1715723935161516032

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