Silver Nanoparticles as Nanoantibiotics: A Comparative Analysis of their Toxicity on Biological Systems of Different Complexity

Silver Nanoparticles as Nanoantibiotics: A Comparative Analysis of their Toxicity on Biological Systems of Different Complexity

Currently, silver nanoparticles (AgNPs) are extensively studied for biomedical applications, but although nanomaterials provide many benefits, recently their comparative toxicity have barely been explored. In the current work, AgNPs toxicity on biological systems of different levels of complexity wa...

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Hauptverfasser: Vázquez-Muñoz, Roberto, Borrego-Rivero, Belén, Juárez-Moreno, Karla Oyuky, García-García, Maritza Roxana, Mota-Morales, Josué David, Bogdanchikova, Nina, Huerta-Saquero, Alejandro
Format: Online
Sprache:eng
Veröffentlicht: Universidad Autónoma de Baja California 2018
Online Zugang:https://recit.uabc.mx/index.php/revista/article/view/26
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spelling recit-article-262022-10-06T22:46:05Z Silver Nanoparticles as Nanoantibiotics: A Comparative Analysis of their Toxicity on Biological Systems of Different Complexity Nanopartículas de plata como nanoantibióticos: Un análisis comparativo de su toxicidad en sistemas biológicos de diferente complejidad Vázquez-Muñoz, Roberto Borrego-Rivero, Belén Juárez-Moreno, Karla Oyuky García-García, Maritza Roxana Mota-Morales, Josué David Bogdanchikova, Nina Huerta-Saquero, Alejandro Silver Nanoparticles Nanotoxicology Biological Systems Complexity Antimicrobial Activity. Nanopartículas de Plata Nanotoxicología Complejidad de Sistemas Biológicos Actividad Antimicrobiana Currently, silver nanoparticles (AgNPs) are extensively studied for biomedical applications, but although nanomaterials provide many benefits, recently their comparative toxicity have barely been explored. In the current work, AgNPs toxicity on biological systems of different levels of complexity was assessed in a comprehensive and comparatively way. The organisms included viruses, bacteria, microalgae, fungi, animal and human cells (including cancer cell lines). We found that growth of biological systems of different taxonomical groups –in vitro, at a cellular level- is inhibited at concentrations of AgNPs within the same order of magnitude (101 μg/ml). Thus, the AgNPs toxicity does not depend on the complexity of the organisms. The fact that cells and virus are inhibited with a concentration of AgNPs within the same order of magnitude could be explained considering that silver affects fundamental structures for cells and virus alike. Actualmente, las nanopartículas de plata (AgNPs) se estudian ampliamente para aplicaciones biomédicas, pero a pesar de que los nanomateriales proporcionan muchos beneficios, recientemente su toxicidad comparativa apenas se ha explorado. En el trabajo actual, la toxicidad de AgNPs en sistemas biológicos de diferentes niveles de complejidad se evaluó de forma exhaustiva y comparativa. Los organismos incluyen virus, bacterias, microalgas, hongos, células animales y humanas (incluidas líneas celulares cancerosas). Encontramos que el crecimiento de los sistemas biológicos de diferentes grupos taxonómicos -in vitro, a nivel celular- se inhibe a concentraciones de AgNP dentro del mismo orden de magnitud (101 μg / ml). Por lo tanto, la toxicidad de AgNPs no depende de la complejidad de los organismos. El hecho de que las células y los virus se inhiban con una concentración de AgNP dentro del mismo orden de magnitud podría explicarse teniendo en cuenta que la plata afecta las estructuras fundamentales de las células y virus por igual. Universidad Autónoma de Baja California 2018-09-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Research article Artículo de investigación application/pdf text/html application/xml https://recit.uabc.mx/index.php/revista/article/view/26 10.37636/recit.v11811 REVISTA DE CIENCIAS TECNOLÓGICAS; Vol. 1 No. 1 (2018): July-September; 8-11 REVISTA DE CIENCIAS TECNOLÓGICAS; Vol. 1 Núm. 1 (2018): Julio-Septiembre; 8-11 2594-1925 eng https://recit.uabc.mx/index.php/revista/article/view/26/29 https://recit.uabc.mx/index.php/revista/article/view/26/75 https://recit.uabc.mx/index.php/revista/article/view/26/128 Copyright (c) 2018 Vázquez-Muñoz Roberto, Borrego-Rivero Belén, Juárez-Moreno Karla Oyuky, García-García Maritza Roxana, Mota Morales Josué David, Bogdanchinkova Nina, Huerta-Saquero Alejandro http://creativecommons.org/licenses/by/4.0
institution RECIT
collection OJS
language eng
format Online
author Vázquez-Muñoz, Roberto
Borrego-Rivero, Belén
Juárez-Moreno, Karla Oyuky
García-García, Maritza Roxana
Mota-Morales, Josué David
Bogdanchikova, Nina
Huerta-Saquero, Alejandro
spellingShingle Vázquez-Muñoz, Roberto
Borrego-Rivero, Belén
Juárez-Moreno, Karla Oyuky
García-García, Maritza Roxana
Mota-Morales, Josué David
Bogdanchikova, Nina
Huerta-Saquero, Alejandro
Silver Nanoparticles as Nanoantibiotics: A Comparative Analysis of their Toxicity on Biological Systems of Different Complexity
author_facet Vázquez-Muñoz, Roberto
Borrego-Rivero, Belén
Juárez-Moreno, Karla Oyuky
García-García, Maritza Roxana
Mota-Morales, Josué David
Bogdanchikova, Nina
Huerta-Saquero, Alejandro
author_sort Vázquez-Muñoz, Roberto
title Silver Nanoparticles as Nanoantibiotics: A Comparative Analysis of their Toxicity on Biological Systems of Different Complexity
title_short Silver Nanoparticles as Nanoantibiotics: A Comparative Analysis of their Toxicity on Biological Systems of Different Complexity
title_full Silver Nanoparticles as Nanoantibiotics: A Comparative Analysis of their Toxicity on Biological Systems of Different Complexity
title_fullStr Silver Nanoparticles as Nanoantibiotics: A Comparative Analysis of their Toxicity on Biological Systems of Different Complexity
title_full_unstemmed Silver Nanoparticles as Nanoantibiotics: A Comparative Analysis of their Toxicity on Biological Systems of Different Complexity
title_sort silver nanoparticles as nanoantibiotics: a comparative analysis of their toxicity on biological systems of different complexity
description Currently, silver nanoparticles (AgNPs) are extensively studied for biomedical applications, but although nanomaterials provide many benefits, recently their comparative toxicity have barely been explored. In the current work, AgNPs toxicity on biological systems of different levels of complexity was assessed in a comprehensive and comparatively way. The organisms included viruses, bacteria, microalgae, fungi, animal and human cells (including cancer cell lines). We found that growth of biological systems of different taxonomical groups –in vitro, at a cellular level- is inhibited at concentrations of AgNPs within the same order of magnitude (101 μg/ml). Thus, the AgNPs toxicity does not depend on the complexity of the organisms. The fact that cells and virus are inhibited with a concentration of AgNPs within the same order of magnitude could be explained considering that silver affects fundamental structures for cells and virus alike.
publisher Universidad Autónoma de Baja California
publishDate 2018
url https://recit.uabc.mx/index.php/revista/article/view/26
_version_ 1792095357853761536

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