Chitosan mucoadhesive films as controlled release system of nystatin for buccal application

Chitosan mucoadhesive films as controlled release system of nystatin for buccal application

Oropharyngeal candidiasis is the most prevalent fungal disease in the world. The formulations of the drug of choice for its treatment have a low residence time and bioavailability at the site of infection. The aim of this study was to prepare and characterize mucoadhesive films of chitosan and polyg...

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Glavni autori: Armenta Rojas, Efraín, Cornejo Bravo, José Manuel, Serrano Medina , Aracely, López Maldonado , Eduardo Alberto, Olivas Sarabia, Amelia, Castillo Martínez, Nydia Alejandra, Vea Barragán, Ayla Carolina
Format: Online
Jezik:spa
Izdano: Universidad Autónoma de Baja California 2021
Online pristup:https://recit.uabc.mx/index.php/revista/article/view/64
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spelling recit-article-642022-10-26T11:34:56Z Chitosan mucoadhesive films as controlled release system of nystatin for buccal application Películas mucoadhesivas de quitosano para la liberación sostenida de nistatina en la cavidad bucal Armenta Rojas, Efraín Cornejo Bravo, José Manuel Serrano Medina , Aracely López Maldonado , Eduardo Alberto Olivas Sarabia, Amelia Castillo Martínez, Nydia Alejandra Vea Barragán, Ayla Carolina Chitosan Polygalacturonic acid Polyelectrolytes Mucoadhesive Films Nystatin Oropharyngeal Candidiasis Sustained release Quitosano Ácido Poligalacturónico Polielectrolitos Nistatina Películas Mucoadhesivos Candidiasis orofaríngea Liberación sostenida Oropharyngeal candidiasis is the most prevalent fungal disease in the world. The formulations of the drug of choice for its treatment have a low residence time and bioavailability at the site of infection. The aim of this study was to prepare and characterize mucoadhesive films of chitosan and polygalacturonic acid by the “Solvent-Casting” technique loaded with nystatin as a sustained release system for the oral cavity. The films obtained were characterized to determine their morphological characteristics, adhesion capacity, and degree of swelling and release profile of the drug. The morphology of the films was determined by scanning electron microscopy, the interaction between the polymers was determined by infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry, additionally, its antimicrobial activity against two Candida species was tested. The obtained films showed mucoadhesion capacity and a sustained release of the drug explained by the Korsemeyer-Peppas model, also a significant antimicrobial activity was found. These findings suggest that chitosan-based films are a possible nystatin release system for the oral cavity. La candidiasis de orofaringe es la enfermedad micótica más prevalente a nivel mundial. Las formulaciones del fármaco de elección para su tratamiento cuentan con un tiempo de residencia y biodisponibilidad bajos en el sitio de la infección. El objetivo de este trabajo fue preparar y caracterizar films con capacidad mucoadhesiva de quitosano y ácido poligalacturónico por la técnica “evaporación del disolvente” conteniendo nistatina como un sistema de liberación sostenida en la cavidad bucal. Las películas obtenidas fueron caracterizadas para determinar sus características morfológicas, capacidad de adherencia, grado de hinchamiento y perfil de liberación del fármaco. La morfología de los films fue determinada por microscopía electrónica de barrido y la interacción entre los polímeros fue determinada por espectroscopía infrarroja, análisis termogravimétrico y calorimetría de escaneo diferencial, adicionalmente se determinó su actividad antimicrobiana contra dos especies de Candida. Las películas obtenidas mostraron capacidad de mucoadhesión y una liberación sostenida del fármaco explicada por el modelo de Korsemeyer-Peppas, también mostraron una actividad antimicrobiana significativa. Estos hallazgos sugieren que las películas con base en quitosano son un posible sistema de liberación de nistatina para la cavidad bucal. Universidad Autónoma de Baja California 2021-01-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html text/xml https://recit.uabc.mx/index.php/revista/article/view/64 10.37636/recit.v41118 REVISTA DE CIENCIAS TECNOLÓGICAS; Vol. 4 No. 1 (2021): January-March; 1-18 REVISTA DE CIENCIAS TECNOLÓGICAS; Vol. 4 Núm. 1 (2021): Enero-Marzo; 1-18 2594-1925 spa https://recit.uabc.mx/index.php/revista/article/view/64/192 https://recit.uabc.mx/index.php/revista/article/view/64/193 https://recit.uabc.mx/index.php/revista/article/view/64/194 Copyright (c) 2021 Efrain Armenta Rojas, Jose Manuel Cornejo Bravo, Aracely Serrano Medina , Eduardo Alberto López Maldonado , Amelia Olivas Sarabia, Nydia Alejandra Castillo Martínez, Ayla Carolina Vea Barragán http://creativecommons.org/licenses/by/4.0
institution RECIT
collection OJS
language spa
format Online
author Armenta Rojas, Efraín
Cornejo Bravo, José Manuel
Serrano Medina , Aracely
López Maldonado , Eduardo Alberto
Olivas Sarabia, Amelia
Castillo Martínez, Nydia Alejandra
Vea Barragán, Ayla Carolina
spellingShingle Armenta Rojas, Efraín
Cornejo Bravo, José Manuel
Serrano Medina , Aracely
López Maldonado , Eduardo Alberto
Olivas Sarabia, Amelia
Castillo Martínez, Nydia Alejandra
Vea Barragán, Ayla Carolina
Chitosan mucoadhesive films as controlled release system of nystatin for buccal application
author_facet Armenta Rojas, Efraín
Cornejo Bravo, José Manuel
Serrano Medina , Aracely
López Maldonado , Eduardo Alberto
Olivas Sarabia, Amelia
Castillo Martínez, Nydia Alejandra
Vea Barragán, Ayla Carolina
author_sort Armenta Rojas, Efraín
title Chitosan mucoadhesive films as controlled release system of nystatin for buccal application
title_short Chitosan mucoadhesive films as controlled release system of nystatin for buccal application
title_full Chitosan mucoadhesive films as controlled release system of nystatin for buccal application
title_fullStr Chitosan mucoadhesive films as controlled release system of nystatin for buccal application
title_full_unstemmed Chitosan mucoadhesive films as controlled release system of nystatin for buccal application
title_sort chitosan mucoadhesive films as controlled release system of nystatin for buccal application
description Oropharyngeal candidiasis is the most prevalent fungal disease in the world. The formulations of the drug of choice for its treatment have a low residence time and bioavailability at the site of infection. The aim of this study was to prepare and characterize mucoadhesive films of chitosan and polygalacturonic acid by the “Solvent-Casting” technique loaded with nystatin as a sustained release system for the oral cavity. The films obtained were characterized to determine their morphological characteristics, adhesion capacity, and degree of swelling and release profile of the drug. The morphology of the films was determined by scanning electron microscopy, the interaction between the polymers was determined by infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry, additionally, its antimicrobial activity against two Candida species was tested. The obtained films showed mucoadhesion capacity and a sustained release of the drug explained by the Korsemeyer-Peppas model, also a significant antimicrobial activity was found. These findings suggest that chitosan-based films are a possible nystatin release system for the oral cavity.
publisher Universidad Autónoma de Baja California
publishDate 2021
url https://recit.uabc.mx/index.php/revista/article/view/64
_version_ 1792095368866955264

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