Preparation of Mucoadhesive Films of Polyelectrolyte Complexes for the Release of Chlorhexidine Diacetate

Preparation of Mucoadhesive Films of Polyelectrolyte Complexes for the Release of Chlorhexidine Diacetate

Polyelectrolyte complexe’s films can be a vehicle for the controlled release of drugs in the oral cavity, seeking the interaction of the film with the epithelium of the buccal mucosa. The bioadhesion phenomenon is the retention of the system at the desired site to achieve liberation. In the present...

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Autores principales: Vea-Barragán, Ayla Carolina, Castillo-Martínez, Nydia Alejandra, Serrano-Medina, Aracely, López-Maldonado, Eduardo Alberto, Meléndez-López, Samuel Guillermo, Cornejo-Bravo, José Manuel
Formato: Online
Lenguaje:spa
Publicado: Universidad Autónoma de Baja California 2020
Acceso en línea:https://recit.uabc.mx/index.php/revista/article/view/7
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id recit-article-7
record_format ojs
institution RECIT
collection OJS
language spa
format Online
author Vea-Barragán, Ayla Carolina
Castillo-Martínez, Nydia Alejandra
Serrano-Medina, Aracely
López-Maldonado, Eduardo Alberto
Meléndez-López, Samuel Guillermo
Cornejo-Bravo, José Manuel
spellingShingle Vea-Barragán, Ayla Carolina
Castillo-Martínez, Nydia Alejandra
Serrano-Medina, Aracely
López-Maldonado, Eduardo Alberto
Meléndez-López, Samuel Guillermo
Cornejo-Bravo, José Manuel
Preparation of Mucoadhesive Films of Polyelectrolyte Complexes for the Release of Chlorhexidine Diacetate
author_facet Vea-Barragán, Ayla Carolina
Castillo-Martínez, Nydia Alejandra
Serrano-Medina, Aracely
López-Maldonado, Eduardo Alberto
Meléndez-López, Samuel Guillermo
Cornejo-Bravo, José Manuel
author_sort Vea-Barragán, Ayla Carolina
title Preparation of Mucoadhesive Films of Polyelectrolyte Complexes for the Release of Chlorhexidine Diacetate
title_short Preparation of Mucoadhesive Films of Polyelectrolyte Complexes for the Release of Chlorhexidine Diacetate
title_full Preparation of Mucoadhesive Films of Polyelectrolyte Complexes for the Release of Chlorhexidine Diacetate
title_fullStr Preparation of Mucoadhesive Films of Polyelectrolyte Complexes for the Release of Chlorhexidine Diacetate
title_full_unstemmed Preparation of Mucoadhesive Films of Polyelectrolyte Complexes for the Release of Chlorhexidine Diacetate
title_sort preparation of mucoadhesive films of polyelectrolyte complexes for the release of chlorhexidine diacetate
description Polyelectrolyte complexe’s films can be a vehicle for the controlled release of drugs in the oral cavity, seeking the interaction of the film with the epithelium of the buccal mucosa. The bioadhesion phenomenon is the retention of the system at the desired site to achieve liberation. In the present work, a release system was developed using polyelectrolyte polymers of opposite charge that form films by ionic complexation. The films were loaded with chlorhexidine diacetate for the treatment of oral infections. The solvent evaporation method was used for the preparation of films, containing arabic gum and chitosan (1: 1) and Noveon AA-1® 2% (w/v), which was included for its mucoadhesive properties. The films were prepared with the same proportions of polymers but adding chlorhexidine diacetate dissolved in ethanol 2% (w/v), before the evaporation of the solvent for the formation of the films. Swelling studies shows that films swell in solutions that simulate oral pH conditions. The films loaded with the drug release in vitro more than 90% of the drug in 24 hours. Microbiological tests showed that films loaded with chlorhexidine diacetate inhibit the growth of E. coli and P. aeruginosa in standardized sensitivity tests. The films studied show suitable characteristics for the release of chlorhexidine diacetate, demonstrating the inhibition of the growth of pathogenic microorganisms, so they have potential to be used in the treatment of patients with oral infections such as gingivitis and periodontal disease. 
publisher Universidad Autónoma de Baja California
publishDate 2020
url https://recit.uabc.mx/index.php/revista/article/view/7
_version_ 1792095370336010240
spelling recit-article-72022-10-20T22:30:08Z Preparation of Mucoadhesive Films of Polyelectrolyte Complexes for the Release of Chlorhexidine Diacetate Preparación de películas mucoadhesivas de complejos de polielectrólitos para la liberación de diacetato de clorhexidina Vea-Barragán, Ayla Carolina Castillo-Martínez, Nydia Alejandra Serrano-Medina, Aracely López-Maldonado, Eduardo Alberto Meléndez-López, Samuel Guillermo Cornejo-Bravo, José Manuel Polyelectrolyte films Mucoadhesion Chlorhexidine diacetate. Películas polielectrolíticas Mucoadhesion Diacetato clorhexidina Polyelectrolyte complexe’s films can be a vehicle for the controlled release of drugs in the oral cavity, seeking the interaction of the film with the epithelium of the buccal mucosa. The bioadhesion phenomenon is the retention of the system at the desired site to achieve liberation. In the present work, a release system was developed using polyelectrolyte polymers of opposite charge that form films by ionic complexation. The films were loaded with chlorhexidine diacetate for the treatment of oral infections. The solvent evaporation method was used for the preparation of films, containing arabic gum and chitosan (1: 1) and Noveon AA-1® 2% (w/v), which was included for its mucoadhesive properties. The films were prepared with the same proportions of polymers but adding chlorhexidine diacetate dissolved in ethanol 2% (w/v), before the evaporation of the solvent for the formation of the films. Swelling studies shows that films swell in solutions that simulate oral pH conditions. The films loaded with the drug release in vitro more than 90% of the drug in 24 hours. Microbiological tests showed that films loaded with chlorhexidine diacetate inhibit the growth of E. coli and P. aeruginosa in standardized sensitivity tests. The films studied show suitable characteristics for the release of chlorhexidine diacetate, demonstrating the inhibition of the growth of pathogenic microorganisms, so they have potential to be used in the treatment of patients with oral infections such as gingivitis and periodontal disease.  Las películas de complejos de polielectrólitos pueden ser un vehículo para liberación controlada de fármacos en la cavidad oral, buscando la interacción de la película con el epitelio de la mucosa bucal, dado que con el fenómeno de bioadhesión se logra la retención del sistema en el sitio deseado para la liberación. En el presente trabajo se desarrolló un sistema de liberación usando polímeros polielectrólitos de carga opuesta que forman películas por complejación iónica. Las películas fueron cargadas con diacetato de clorhexidina para el tratamiento de infecciones bucales. Se empleó el método evaporación de solvente para la preparación de las películas, conteniendo goma arábiga y quitosano (1:1) y Noveon AA-1® 2% (p/v), este último se incluyó por sus propiedades mucoadhesivas. Se prepararon películas con las mismas proporciones de polímeros, pero agregando diacetato de clorhexidina disuelto en etanol 2% w/v, previo a la evaporación del disolvente para la formación de las películas. Los estudios de hinchamiento muestran que las películas se hinchan en soluciones que simulan las condiciones de pH bucal. Las películas cargadas con el fármaco liberan in vitro, más del 90 % del fármaco en 24 horas. Las pruebas microbiológicas mostraron que las películas cargadas con diacetato de clorhexidina inhiben el crecimiento E. coli y P. aeruginosa, en las pruebas de sensibilidad estandarizadas. Las películas estudiadas muestran características adecuadas para la liberación de diacetato de clorhexidina, demostrando la inhibición del crecimiento de microrganismos patógenos por lo que tiene potencial para utilizarse en el tratamiento de pacientes con infecciones bucales tales como gingivitis y enfermedad periodontal. Universidad Autónoma de Baja California 2020-01-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html application/xml https://recit.uabc.mx/index.php/revista/article/view/7 10.37636/recit.v311022 REVISTA DE CIENCIAS TECNOLÓGICAS; Vol. 3 No. 1 (2020): January-March; 10-22 REVISTA DE CIENCIAS TECNOLÓGICAS; Vol. 3 Núm. 1 (2020): Enero-Marzo; 10-22 2594-1925 spa https://recit.uabc.mx/index.php/revista/article/view/7/18 https://recit.uabc.mx/index.php/revista/article/view/7/45 https://recit.uabc.mx/index.php/revista/article/view/7/158 Copyright (c) 2020 Ayla Carolina Vea-Barragán, Nydia Alejandra Castillo-Martínez, Aracely Serrano-Medina, Eduardo Alberto López-Maldonado, Samuel Guillermo Meléndez-López, José Manuel Cornejo-Bravo http://creativecommons.org/licenses/by/4.0

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