Chitosan mucoadhesive films as controlled release system of nystatin for buccal application
Oropharyngeal candidiasis is the most prevalent fungal disease in the world. The formulations of the drug of choice for its treatment have a low residence time and bioavailability at the site of infection. The aim of this study was to prepare and characterize mucoadhesive films of chitosan and polyg...
Tallennettuna:
| Päätekijät: | , , , , , , |
|---|---|
| Aineistotyyppi: | info:eu-repo/semantics/article |
| Kieli: | spa |
| Julkaistu: |
Universidad Autónoma de Baja California
2021
|
| Aiheet: | |
| Linkit: | https://recit.uabc.mx/index.php/revista/article/view/tlba2 |
| Tagit: |
Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!
|
| id |
repositorioinstitucional-20.500.12930-7019 |
|---|---|
| record_format |
dspace |
| institution |
Repositorio Institucional |
| collection |
DSpace |
| language |
spa |
| topic |
Quitosano Acido Poligalacturónico Polielectrolitos Nistatina Películas Mucoadhesivos Candidiasis Orofaríngea Liberación Sostenida Chitosan Polygalacturonic acid Polyelectrolytes Mucoadhesive Films Nystatin Oropharyngeal Candidiasis Sustained release |
| spellingShingle |
Quitosano Acido Poligalacturónico Polielectrolitos Nistatina Películas Mucoadhesivos Candidiasis Orofaríngea Liberación Sostenida Chitosan Polygalacturonic acid Polyelectrolytes Mucoadhesive Films Nystatin Oropharyngeal Candidiasis Sustained release Armenta Rojas, Efrain Cornejo Bravo, Jose Manuel Serrano Medina , Aracely López Maldonado , Eduardo Alberto Olivas Sarabia, Amelia Castillo Martínez, Nydia Alejandra Vea Barragán, Ayla Carolina Chitosan mucoadhesive films as controlled release system of nystatin for buccal application |
| description |
Oropharyngeal candidiasis is the most prevalent fungal disease in the world. The formulations of the drug of choice for its treatment have a low residence time and bioavailability at the site of infection. The aim of this study was to prepare and characterize mucoadhesive films of chitosan and polygalacturonic acid by the “Solvent-Casting” technique loaded with nystatin as a sustained release system for the oral cavity. The films obtained were characterized to determine their morphological characteristics, adhesion capacity, and degree of swelling and release profile of the drug. The morphology of the films was determined by scanning electron microscopy, the interaction between the polymers was determined by infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry, additionally, its antimicrobial activity against two Candida species was tested. The obtained films showed mucoadhesion capacity and a sustained release of the drug explained by the Korsemeyer-Peppas model, also a significant antimicrobial activity was found. These findings suggest that chitosan-based films are a possible nystatin release system for the oral cavity. |
| format |
info:eu-repo/semantics/article |
| author |
Armenta Rojas, Efrain Cornejo Bravo, Jose Manuel Serrano Medina , Aracely López Maldonado , Eduardo Alberto Olivas Sarabia, Amelia Castillo Martínez, Nydia Alejandra Vea Barragán, Ayla Carolina |
| author_facet |
Armenta Rojas, Efrain Cornejo Bravo, Jose Manuel Serrano Medina , Aracely López Maldonado , Eduardo Alberto Olivas Sarabia, Amelia Castillo Martínez, Nydia Alejandra Vea Barragán, Ayla Carolina |
| author_sort |
Armenta Rojas, Efrain |
| title |
Chitosan mucoadhesive films as controlled release system of nystatin for buccal application |
| title_short |
Chitosan mucoadhesive films as controlled release system of nystatin for buccal application |
| title_full |
Chitosan mucoadhesive films as controlled release system of nystatin for buccal application |
| title_fullStr |
Chitosan mucoadhesive films as controlled release system of nystatin for buccal application |
| title_full_unstemmed |
Chitosan mucoadhesive films as controlled release system of nystatin for buccal application |
| title_sort |
chitosan mucoadhesive films as controlled release system of nystatin for buccal application |
| publisher |
Universidad Autónoma de Baja California |
| publishDate |
2021 |
| url |
https://recit.uabc.mx/index.php/revista/article/view/tlba2 |
| _version_ |
1792609339533426688 |
| spelling |
repositorioinstitucional-20.500.12930-70192023-05-09T14:35:07Z Chitosan mucoadhesive films as controlled release system of nystatin for buccal application Películas mucoadhesivas de quitosano para la liberación sostenida de nistatina en la cavidad bucal Armenta Rojas, Efrain Cornejo Bravo, Jose Manuel Serrano Medina , Aracely López Maldonado , Eduardo Alberto Olivas Sarabia, Amelia Castillo Martínez, Nydia Alejandra Vea Barragán, Ayla Carolina Quitosano Acido Poligalacturónico Polielectrolitos Nistatina Películas Mucoadhesivos Candidiasis Orofaríngea Liberación Sostenida Chitosan Polygalacturonic acid Polyelectrolytes Mucoadhesive Films Nystatin Oropharyngeal Candidiasis Sustained release Oropharyngeal candidiasis is the most prevalent fungal disease in the world. The formulations of the drug of choice for its treatment have a low residence time and bioavailability at the site of infection. The aim of this study was to prepare and characterize mucoadhesive films of chitosan and polygalacturonic acid by the “Solvent-Casting” technique loaded with nystatin as a sustained release system for the oral cavity. The films obtained were characterized to determine their morphological characteristics, adhesion capacity, and degree of swelling and release profile of the drug. The morphology of the films was determined by scanning electron microscopy, the interaction between the polymers was determined by infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry, additionally, its antimicrobial activity against two Candida species was tested. The obtained films showed mucoadhesion capacity and a sustained release of the drug explained by the Korsemeyer-Peppas model, also a significant antimicrobial activity was found. These findings suggest that chitosan-based films are a possible nystatin release system for the oral cavity. La candidiasis de orofaringe es la enfermedad micótica más prevalente a nivel mundial. Las formulaciones del fármaco de elección para su tratamiento cuentan con un tiempo de residencia y biodisponibilidad bajos en el sitio de la infección. El objetivo de este trabajo fue preparar y caracterizar films con capacidad mucoadhesiva de quitosano y ácido poligalacturónico por la técnica “evaporación del disolvente” conteniendo nistatina como un sistema de liberación sostenida en la cavidad bucal. Las películas obtenidas fueron caracterizadas para determinar sus características morfológicas, capacidad de adherencia, grado de hinchamiento y perfil de liberación del fármaco. La morfología de los films fue determinada por microscopía electrónica de barrido y la interacción entre los polímeros fue determinada por espectroscopía infrarroja, análisis termogravimétrico y calorimetría de escaneo diferencial, adicionalmente se determinó su actividad antimicrobiana contra dos especies de Candida. Las películas obtenidas mostraron capacidad de mucoadhesión y una liberación sostenida del fármaco explicada por el modelo de Korsemeyer-Peppas, también mostraron una actividad antimicrobiana significativa. Estos hallazgos sugieren que las películas con base en quitosano son un posible sistema de liberación de nistatina para la cavidad bucal. 2021-01-15 2021-06-03T03:52:34Z 2021-06-03T03:52:34Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://recit.uabc.mx/index.php/revista/article/view/tlba2 10.37636/recit.v41118 https://hdl.handle.net/20.500.12930/7019 spa https://recit.uabc.mx/index.php/revista/article/view/tlba2/tlba2 https://recit.uabc.mx/index.php/revista/article/view/tlba2/tlba2-html https://recit.uabc.mx/index.php/revista/article/view/tlba2/tlba2-xml Copyright (c) 2021 Efrain Armenta Rojas, Jose Manuel Cornejo Bravo, Aracely Serrano Medina , Eduardo Alberto López Maldonado , Amelia Olivas Sarabia, Nydia Alejandra Castillo Martínez, Ayla Carolina Vea Barragán http://creativecommons.org/licenses/by/4.0 application/pdf text/html text/xml Universidad Autónoma de Baja California REVISTA DE CIENCIAS TECNOLÓGICAS; Vol. 4 No. 1 (2021); 1-18 REVISTA DE CIENCIAS TECNOLÓGICAS; Vol. 4 Núm. 1 (2021); 1-18 2594-1925 |
@UABCInstitucional
UABC_Oficial
@UABC_Oficial
Tel: +52 686 551 82 00
cienciaabierta@uabc.edu.mx