Toxicity evaluation of thermosensitive nanogels in an in vivo model

Toxicity evaluation of thermosensitive nanogels in an in vivo model

This study uses C. elegans to assess the toxicity of copolymeric nanogels (NG) of N-isopropylacrylamide (NIPAAm) and 2-(diethylamino)ethyl methacrylate (DEAEM), prepared by surfactant-free emulsion polymerization using polyethylene glycol monomethyl ether methacrylate (PEGMA) as a reactive stabilize...

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Autores principales: Montañez Rios, Alondra, Serrano Medina , Aracely, Irache , Juan M., Martínez López , Ana Luisa, Rivero Espejel , Ignacio Alfredo, Cornejo Bravo , Jose Manuel
Formato: Online
Lenguaje:spa
Publicado: Universidad Autónoma de Baja California 2022
Acceso en línea:https://recit.uabc.mx/index.php/revista/article/view/236
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Sumario:This study uses C. elegans to assess the toxicity of copolymeric nanogels (NG) of N-isopropylacrylamide (NIPAAm) and 2-(diethylamino)ethyl methacrylate (DEAEM), prepared by surfactant-free emulsion polymerization using polyethylene glycol monomethyl ether methacrylate (PEGMA) as a reactive stabilizer. Nematodes ingested fluorescein-labeled NG, as demonstrated by fluorescence microscopy. Two different initiators, cationic and anionic, were used to initiate the synthesis of the NG. The results indicate that both types of NG affect the size and reproducibility of nematodes. C. elegans is a potential multicellular model to evaluate the toxicity of sensitive NG, avoiding the use of mammals for evaluations.

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