Toxicity evaluation of thermosensitive nanogels in an in vivo model

Toxicity evaluation of thermosensitive nanogels in an in vivo model

This study uses C. elegans to assess the toxicity of copolymeric nanogels (NG) of N-isopropylacrylamide (NIPAAm) and 2-(diethylamino)ethyl methacrylate (DEAEM), prepared by surfactant-free emulsion polymerization using polyethylene glycol monomethyl ether methacrylate (PEGMA) as a reactive stabilize...

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Autores principales: Montañez Rios, Alondra, Serrano Medina , Aracely, Irache , Juan M., Martínez López , Ana Luisa, Rivero Espejel , Ignacio Alfredo, Cornejo Bravo , Jose Manuel
Formato: Online
Lenguaje:spa
Publicado: Universidad Autónoma de Baja California 2022
Acceso en línea:https://recit.uabc.mx/index.php/revista/article/view/236
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spelling recit-article-2362023-07-31T21:05:46Z Toxicity evaluation of thermosensitive nanogels in an in vivo model Evaluación de toxicidad de nanogeles termosensibles en modelo in vivo Montañez Rios, Alondra Serrano Medina , Aracely Irache , Juan M. Martínez López , Ana Luisa Rivero Espejel , Ignacio Alfredo Cornejo Bravo , Jose Manuel Nanogeles C. elegans NIPAAm Toxicidad Nanogels C. elegans NIPAAm Toxicity This study uses C. elegans to assess the toxicity of copolymeric nanogels (NG) of N-isopropylacrylamide (NIPAAm) and 2-(diethylamino)ethyl methacrylate (DEAEM), prepared by surfactant-free emulsion polymerization using polyethylene glycol monomethyl ether methacrylate (PEGMA) as a reactive stabilizer. Nematodes ingested fluorescein-labeled NG, as demonstrated by fluorescence microscopy. Two different initiators, cationic and anionic, were used to initiate the synthesis of the NG. The results indicate that both types of NG affect the size and reproducibility of nematodes. C. elegans is a potential multicellular model to evaluate the toxicity of sensitive NG, avoiding the use of mammals for evaluations. Este estudio utiliza C. elegans para evaluar la toxicidad de los nanogeles (NG) copoliméricos de N-isopropilacrilamida (NIPAAm) y metacrilato de 2-(dietilamino)etilo (DEAEM), preparados mediante polimerización en emulsión sin tensoactivo utilizando polietilenglicol monometil éter metacrilato (PEGMA) como estabilizador reactivo. Los nematodos ingirieron NG marcados con fluoresceína, como se demostró mediante microscopía de fluorescencia. Se utilizaron dos iniciadores diferentes, catiónicos y aniónicos para iniciar la síntesis de los NG. Los resultados demuestran que ambos tipos de NG afectan el tamaño y la reproductividad de los nematodos. C. elegans es un modelo pluricelular potencial para evaluar la toxicidad de los NG sensibles, evitando el uso de mamíferos para las evaluaciones. Universidad Autónoma de Baja California 2022-10-09 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html text/xml https://recit.uabc.mx/index.php/revista/article/view/236 10.37636/recit.v5n3e236 REVISTA DE CIENCIAS TECNOLÓGICAS; Vol. 5 No. 3 (2022): July-September; e236 REVISTA DE CIENCIAS TECNOLÓGICAS; Vol. 5 Núm. 3 (2022): Julio-Septiembre; e236 2594-1925 spa https://recit.uabc.mx/index.php/revista/article/view/236/389 https://recit.uabc.mx/index.php/revista/article/view/236/391 https://recit.uabc.mx/index.php/revista/article/view/236/445 Copyright (c) 2022 Alondra Montañez Rios, Aracely Serrano Medina , Juan M. Irache , Ana Luisa Martínez López , Ignacio Alfredo Rivero Espejel , Jose Manuel Cornejo Bravo https://creativecommons.org/licenses/by/4.0
institution RECIT
collection OJS
language spa
format Online
author Montañez Rios, Alondra
Serrano Medina , Aracely
Irache , Juan M.
Martínez López , Ana Luisa
Rivero Espejel , Ignacio Alfredo
Cornejo Bravo , Jose Manuel
spellingShingle Montañez Rios, Alondra
Serrano Medina , Aracely
Irache , Juan M.
Martínez López , Ana Luisa
Rivero Espejel , Ignacio Alfredo
Cornejo Bravo , Jose Manuel
Toxicity evaluation of thermosensitive nanogels in an in vivo model
author_facet Montañez Rios, Alondra
Serrano Medina , Aracely
Irache , Juan M.
Martínez López , Ana Luisa
Rivero Espejel , Ignacio Alfredo
Cornejo Bravo , Jose Manuel
author_sort Montañez Rios, Alondra
title Toxicity evaluation of thermosensitive nanogels in an in vivo model
title_short Toxicity evaluation of thermosensitive nanogels in an in vivo model
title_full Toxicity evaluation of thermosensitive nanogels in an in vivo model
title_fullStr Toxicity evaluation of thermosensitive nanogels in an in vivo model
title_full_unstemmed Toxicity evaluation of thermosensitive nanogels in an in vivo model
title_sort toxicity evaluation of thermosensitive nanogels in an in vivo model
description This study uses C. elegans to assess the toxicity of copolymeric nanogels (NG) of N-isopropylacrylamide (NIPAAm) and 2-(diethylamino)ethyl methacrylate (DEAEM), prepared by surfactant-free emulsion polymerization using polyethylene glycol monomethyl ether methacrylate (PEGMA) as a reactive stabilizer. Nematodes ingested fluorescein-labeled NG, as demonstrated by fluorescence microscopy. Two different initiators, cationic and anionic, were used to initiate the synthesis of the NG. The results indicate that both types of NG affect the size and reproducibility of nematodes. C. elegans is a potential multicellular model to evaluate the toxicity of sensitive NG, avoiding the use of mammals for evaluations.
publisher Universidad Autónoma de Baja California
publishDate 2022
url https://recit.uabc.mx/index.php/revista/article/view/236
_version_ 1792095379310772224

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