Layered double hydroxides: application in the inhibition of coliforms

Layered double hydroxides: application in the inhibition of coliforms

In this work, the preparation of different organic/inorganic hybrid materials and their evaluation as bactericides against Escherichia coli (E. coli) and Salmonella typhi (S. typhi) was studied. The main objective of the present investigation was to synthesize and characterize biocompatible hybrid m...

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Autores principales: Guerra-González, Roberto, Lemus-Solorio, Martha Angélica, Rivera-Rojas, José Luis, Lemus-Solorio, Alfonso, Mondragón-Herrera, América Abisay, Martínez-Cinco, Marco Antonio
Formato: Online
Lenguaje:eng
Publicado: Universidad Autónoma de Baja California 2021
Acceso en línea:https://recit.uabc.mx/index.php/revista/article/view/83
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id recit-article-83
record_format ojs
institution RECIT
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language eng
format Online
author Guerra-González, Roberto
Lemus-Solorio, Martha Angélica
Rivera-Rojas, José Luis
Lemus-Solorio, Alfonso
Mondragón-Herrera, América Abisay
Martínez-Cinco, Marco Antonio
spellingShingle Guerra-González, Roberto
Lemus-Solorio, Martha Angélica
Rivera-Rojas, José Luis
Lemus-Solorio, Alfonso
Mondragón-Herrera, América Abisay
Martínez-Cinco, Marco Antonio
Layered double hydroxides: application in the inhibition of coliforms
author_facet Guerra-González, Roberto
Lemus-Solorio, Martha Angélica
Rivera-Rojas, José Luis
Lemus-Solorio, Alfonso
Mondragón-Herrera, América Abisay
Martínez-Cinco, Marco Antonio
author_sort Guerra-González, Roberto
title Layered double hydroxides: application in the inhibition of coliforms
title_short Layered double hydroxides: application in the inhibition of coliforms
title_full Layered double hydroxides: application in the inhibition of coliforms
title_fullStr Layered double hydroxides: application in the inhibition of coliforms
title_full_unstemmed Layered double hydroxides: application in the inhibition of coliforms
title_sort layered double hydroxides: application in the inhibition of coliforms
description In this work, the preparation of different organic/inorganic hybrid materials and their evaluation as bactericides against Escherichia coli (E. coli) and Salmonella typhi (S. typhi) was studied. The main objective of the present investigation was to synthesize and characterize biocompatible hybrid materials that immobilize molecules with antibacterial activity in inorganic lamellar double hydroxides based on inorganic lamellar matrices and to evaluate their antibacterial activity against Escherichia coli (E. coli) and Salmonella typhi (S. typhi). The hybrid materials consist of the association of an inorganic lamellar double hydroxide, or hydrotalcite-type compounds, with organic molecules with antibacterial activity, hosted in solids. Lamellar double hydroxides (LDH) are synthetic structures formed by positively charged metal hydroxide films that are stabilized with interlamellar anions. Different hybrid materials have been studied from hydrotalcite-type compounds, such as MgAl, ZnAl, and MgFeAl, containing organic species of sodium cephalexin and nalidixic and pipemidic acids. The intercalation of the different anions was performed by one of the different existing methods: coprecipitation of the hydrotalcite-type compounds in the presence of the molecule of interest, and by the memory effect. The characterization of the materials was carried out by X-ray diffraction, IR, and solid nuclear magnetic resonance spectroscopy, specifically analyzing the 27Al and 13C nuclei, and thermogravimetric analysis. The evaluation of the antibacterial activity of these materials was evaluated on cultures of Escherichia coli (E. coli) and Salmonella typhi (S. typhi) strains. The antibacterial activity of the tested hybrid systems is not always a direct function of the amount of antibiotic intercalated. It was obtained that the LDH ZnAl- NADmem presents a controlled release since when the material was exposed three times against Escherichia coli (E. coli) bacteria, it continued eliminating bacteria, presenting a bacteriostatic effect in the third exposure, since it did not eliminate bacteria.
publisher Universidad Autónoma de Baja California
publishDate 2021
url https://recit.uabc.mx/index.php/revista/article/view/83
_version_ 1792095370864492544
spelling recit-article-832022-10-26T18:20:08Z Layered double hydroxides: application in the inhibition of coliforms Hidróxidos dobles estratificados: aplicación en la inhibición de coliformes Guerra-González, Roberto Lemus-Solorio, Martha Angélica Rivera-Rojas, José Luis Lemus-Solorio, Alfonso Mondragón-Herrera, América Abisay Martínez-Cinco, Marco Antonio inhibición materiales híbridos antibacteriano inhibition hybrid materials antibacterial In this work, the preparation of different organic/inorganic hybrid materials and their evaluation as bactericides against Escherichia coli (E. coli) and Salmonella typhi (S. typhi) was studied. The main objective of the present investigation was to synthesize and characterize biocompatible hybrid materials that immobilize molecules with antibacterial activity in inorganic lamellar double hydroxides based on inorganic lamellar matrices and to evaluate their antibacterial activity against Escherichia coli (E. coli) and Salmonella typhi (S. typhi). The hybrid materials consist of the association of an inorganic lamellar double hydroxide, or hydrotalcite-type compounds, with organic molecules with antibacterial activity, hosted in solids. Lamellar double hydroxides (LDH) are synthetic structures formed by positively charged metal hydroxide films that are stabilized with interlamellar anions. Different hybrid materials have been studied from hydrotalcite-type compounds, such as MgAl, ZnAl, and MgFeAl, containing organic species of sodium cephalexin and nalidixic and pipemidic acids. The intercalation of the different anions was performed by one of the different existing methods: coprecipitation of the hydrotalcite-type compounds in the presence of the molecule of interest, and by the memory effect. The characterization of the materials was carried out by X-ray diffraction, IR, and solid nuclear magnetic resonance spectroscopy, specifically analyzing the 27Al and 13C nuclei, and thermogravimetric analysis. The evaluation of the antibacterial activity of these materials was evaluated on cultures of Escherichia coli (E. coli) and Salmonella typhi (S. typhi) strains. The antibacterial activity of the tested hybrid systems is not always a direct function of the amount of antibiotic intercalated. It was obtained that the LDH ZnAl- NADmem presents a controlled release since when the material was exposed three times against Escherichia coli (E. coli) bacteria, it continued eliminating bacteria, presenting a bacteriostatic effect in the third exposure, since it did not eliminate bacteria. En este trabajo se estudió la preparación de diferentes materiales híbridos orgánicos / inorgánicos y su evaluación como bactericidas frente a Escherichia coli (E. coli) y Salmonella typhi (S. typhi). El objetivo principal de la presente investigación fue sintetizar y caracterizar materiales híbridos biocompatibles que inmovilizan moléculas con actividad antibacteriana en matrices lamelares inorgánicas basadas en dobles hidróxidos lamelares inorgánicos y evaluar su actividad antibacteriana frente a Escherichia coli (E. coli) y Salmonella typhi (S. typhi). Los materiales híbridos consisten en la asociación de un doble hidróxido laminar inorgánico, o compuestos tipo hidrotalcita, con moléculas orgánicas con actividad antibacteriana, alojadas en sólidos. Los hidróxidos dobles lamelares (LDH) son estructuras sintéticas formadas por películas de hidróxido metálico con carga positiva que se estabilizan con aniones interlaminares. Se han estudiado diferentes materiales híbridos a partir de compuestos tipo hidrotalcita, como MgAl, ZnAl y MgFeAl, que contienen especies orgánicas de cefalexina sódica y ácidos nalidíxico y pipemídico. La intercalación de los diferentes aniones se realizó mediante uno de los diferentes métodos existentes: la coprecipitación de los compuestos tipo hidrotalcita en presencia de la molécula de interés y por el efecto memoria. La caracterización de los materiales se realizó mediante difracción de rayos X, espectroscopia de IR y resonancia magnética nuclear sólida, analizando específicamente los núcleos 27Al y 13C, y análisis termogravimétrico. La evaluación de la actividad antibacteriana de estos materiales se evaluó en cultivos de cepas de Escherichia coli (E. coli) y Salmonella typhi (S. typhi). La actividad antibacteriana de los sistemas híbridos probados no siempre es una función directa de la cantidad de antibiótico intercalado. Se obtuvo que el LDH ZnAl-NADmem presenta una liberación controlada, ya que cuando el material fue expuesto tres veces contra la bacteria Escherichia coli (E. coli), continuó eliminando bacterias, presentando un efecto bacteriostático en la tercera exposición, ya que no eliminar las bacterias. Universidad Autónoma de Baja California 2021-08-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf text/html text/xml https://recit.uabc.mx/index.php/revista/article/view/83 10.37636/recit.v43157170 REVISTA DE CIENCIAS TECNOLÓGICAS; Vol. 4 No. 3 (2021): July-September; 157-170 REVISTA DE CIENCIAS TECNOLÓGICAS; Vol. 4 Núm. 3 (2021): Julio-Septiembre; 157-170 2594-1925 eng https://recit.uabc.mx/index.php/revista/article/view/83/224 https://recit.uabc.mx/index.php/revista/article/view/83/233 https://recit.uabc.mx/index.php/revista/article/view/83/234 Copyright (c) 2021 Roberto Guerra-González, Martha Angélica Lemus-Solorio, José Luis Rivera-Rojas, Alfonso Lemus-Solorio, América Abisay Mondragón-Herrera, Marco Antonio Martínez-Cinco https://creativecommons.org/licenses/by/4.0

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