Diabetic foot ulcers treatment with silver nanoparticles
Diabetic foot ulcers are highly susceptible to microbial infections and are the leading cause of lower limb hospitalization and amputation in diabetic patients. Due to their antimicrobial and anti-inflammatory properties, silver nanoparticles (AgNPs) are the most widely used nanomaterial in biomedic...
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Universidad Autónoma de Baja California
2019
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repositorioinstitucional-20.500.12930-70122023-05-09T14:35:06Z Diabetic foot ulcers treatment with silver nanoparticles Tratamiento de las úlceras del pie diabético con nanopartículas de plata Almonaci Hernández, Cesar Alejandro Cabrera Torres, Isis Marion López-Acevedo, Rosangela Juárez-Moreno, Karla Oyuki Castañeda-Juárez, Martin E. Almanza-Reyes, Horacio Pestryakov, Alexey Bogdanchikova, Nina Diabetic Foot Ulcers Diabetes Mellitus Silver Nanoparticles Nanomedicine Chronic Ulcers. Red Internacional de Bionanotecnología Diabetic foot ulcers are highly susceptible to microbial infections and are the leading cause of lower limb hospitalization and amputation in diabetic patients. Due to their antimicrobial and anti-inflammatory properties, silver nanoparticles (AgNPs) are the most widely used nanomaterial in biomedicine. Herein, we present the usage of AgNPs for the treatment of diabetic foot ulcers with a stage II in Wagner classification. In addition to conventional antibiotic treatment, the ulcers were treated with topical administration of AgNPs at a concentration of 1.2 mg/ml of metallic silver. The results showed a significant improvement in the evolution of the ulcers, where the edges of the lesion were effectively approached, granulation tissue being observed, edema decreased and fibrin plaques. These results form the basis for further studies on the use of AgNPs for the treatment of chronic ulcers of different origins. Las úlceras del pie diabético son altamente susceptibles a infecciones microbianas y son la principal causa de hospitalización y amputación de extremidades inferiores en pacientes diabéticos. Debido a sus propiedades antimicrobianas y anti-inflamatorias, las nanopartículas de plata (AgNPs) son el nanomaterial más utilizado en biomedicina. En este trabajo presentamos el uso de AgNPs para el tratamiento de úlceras de pie diabético grado II de la clasificación de Wagner. Además del tratamiento con antibióticos convencionales, las úlceras fueron tratadas mediante la administración tópica de AgNPs a una concentración de 1.2 mg/mL de plata metálica. Los resultados obtenidos, revelan una mejora significativa en la evolución de las úlceras, en donde los bordes de la lesión se acercaron de manera efectiva, observándose tejido de granulación, disminución del edema y placas de fibrina. Estos resultados constituyen la base para nuevos estudios sobre el uso de AgNPs para el tratamiento de úlceras crónicas de diferentes orígenes. 2019-01-20 2021-06-03T03:52:32Z 2021-06-03T03:52:32Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Research article Articulo de Investigación https://recit.uabc.mx/index.php/revista/article/view/oba8 10.37636/recit.v212025 https://hdl.handle.net/20.500.12930/7012 eng https://recit.uabc.mx/index.php/revista/article/view/oba8/20-25 https://recit.uabc.mx/index.php/revista/article/view/oba8/html https://recit.uabc.mx/index.php/revista/article/view/oba8/OBA8 Copyright (c) 2019 Almonaci Hernández Cesar Alejandro, Cabrera Torres Isis Marion, López-Acevedo Rosangela, Juárez-Moreno Karla Oyuki, Castañeda-Juárez Martin E., Almanza-Reyes Horacio, Pestryakov Alexey, Bogdanchikova Nina http://creativecommons.org/licenses/by/4.0 application/pdf text/html application/xml Universidad Autónoma de Baja California REVISTA DE CIENCIAS TECNOLÓGICAS; Vol. 2 No. 1 (2019); 20-25 REVISTA DE CIENCIAS TECNOLÓGICAS; Vol. 2 Núm. 1 (2019); 20-25 2594-1925 |
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Diabetic Foot Ulcers Diabetes Mellitus Silver Nanoparticles Nanomedicine Chronic Ulcers. Red Internacional de Bionanotecnología |
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Diabetic Foot Ulcers Diabetes Mellitus Silver Nanoparticles Nanomedicine Chronic Ulcers. Red Internacional de Bionanotecnología Almonaci Hernández, Cesar Alejandro Cabrera Torres, Isis Marion López-Acevedo, Rosangela Juárez-Moreno, Karla Oyuki Castañeda-Juárez, Martin E. Almanza-Reyes, Horacio Pestryakov, Alexey Bogdanchikova, Nina Diabetic foot ulcers treatment with silver nanoparticles |
description |
Diabetic foot ulcers are highly susceptible to microbial infections and are the leading cause of lower limb hospitalization and amputation in diabetic patients. Due to their antimicrobial and anti-inflammatory properties, silver nanoparticles (AgNPs) are the most widely used nanomaterial in biomedicine. Herein, we present the usage of AgNPs for the treatment of diabetic foot ulcers with a stage II in Wagner classification. In addition to conventional antibiotic treatment, the ulcers were treated with topical administration of AgNPs at a concentration of 1.2 mg/ml of metallic silver. The results showed a significant improvement in the evolution of the ulcers, where the edges of the lesion were effectively approached, granulation tissue being observed, edema decreased and fibrin plaques. These results form the basis for further studies on the use of AgNPs for the treatment of chronic ulcers of different origins. |
format |
info:eu-repo/semantics/article |
author |
Almonaci Hernández, Cesar Alejandro Cabrera Torres, Isis Marion López-Acevedo, Rosangela Juárez-Moreno, Karla Oyuki Castañeda-Juárez, Martin E. Almanza-Reyes, Horacio Pestryakov, Alexey Bogdanchikova, Nina |
author_facet |
Almonaci Hernández, Cesar Alejandro Cabrera Torres, Isis Marion López-Acevedo, Rosangela Juárez-Moreno, Karla Oyuki Castañeda-Juárez, Martin E. Almanza-Reyes, Horacio Pestryakov, Alexey Bogdanchikova, Nina |
author_sort |
Almonaci Hernández, Cesar Alejandro |
title |
Diabetic foot ulcers treatment with silver nanoparticles |
title_short |
Diabetic foot ulcers treatment with silver nanoparticles |
title_full |
Diabetic foot ulcers treatment with silver nanoparticles |
title_fullStr |
Diabetic foot ulcers treatment with silver nanoparticles |
title_full_unstemmed |
Diabetic foot ulcers treatment with silver nanoparticles |
title_sort |
diabetic foot ulcers treatment with silver nanoparticles |
publisher |
Universidad Autónoma de Baja California |
publishDate |
2019 |
url |
https://recit.uabc.mx/index.php/revista/article/view/oba8 |
_version_ |
1792608724643217408 |